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Abstract
Thymosin alpha-1 (Tal) significantly enhances the fertilizability of sperm from fertile men by increasing capacitation and/or acrosome reaction. The present study was conducted to investigate the effect of Tal on fertilizing capacity of sperm of infertile men using the sperm penetration assay (SPA) in a multicenter clinical trial. Tal significantly (p =. 0006 to <. 0001) increased (31 to 45%) fertilizing capacity of sperm of 76% (50/68) of infertile men as defined by the sperm penetration index in SPA. The enhancing effect of Tal and the degree of enhancement depended on the Tal concentration in the seminal plasma, since these parameters showed a significant intercorrelation (r =. 65 to. 74, p =. 039 to. 01). It would appear that Tal may have clinical application in the diagnosis and treatment of male infertility especially mediated through defective sperm function.