Miller Fisher Syndrome Presenting with Pain on Eye Movement

Abstract

A 19-year-old man noticed a severe tingling pain associated with eye movement six days after the onset of a mild gait disturbance. The pain disappeared when his eyes were still. Physical examination revealed a full range of eye movements (although there was diplopia), mild muscle weakness in the extremities, ataxia, decreased vibration sense and areflexia. Serum anti-GA1 IgG was strongly positive, and anti-GM1 and GQ1b IgG were weakly positive. He was diagnosed with Miller Fisher syndrome and treated with intravenous immunoglobulin, whereupon his symptoms, including the tingling pain, improved within a week.

KEYWORDS::

• Miller Fisher syndrome
• headache
• anti-ganglioside antibodies

ACKNOWLEDGEMENT

We thank Dr. Susumu Kusunoki (Department of Neurology, Kinki University School of Medicine) for his examinations of anti-glycolipid antibodies in the present patient.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.