Giant Chondroma of the Saddle Area: Case Report and Literature Review*

Abstract

A 63-year-old man presented with sexual dysfunction of 6-year duration, 5-year history of bilateral vision loss, and left nasal obstruction for 3 years. Brain computed tomography and magnetic resonance imaging showed a large mass lesion in the saddle area and extending upward to the dorsum sellae, bilateral cavernous sinus, and suprasellar region, and down into the sphenoid sinus and nasal cavity; the optic nerves and optic chiasm were elevated upward and compressed. Endocrine tests indicated that all serum level of anterior pituitary hormones decreased. The preoperative diagnosis included invasive pituitary adenoma, chordoma, osteosarcoma, chondrosarcoma, and craniopharyngioma. The tumour was subtotally removed through transsphenoidal approach. Histopathology examination revealed a chondroma. Postoperatively, the patient was stable and his visual acuity and visual field defect improved and his pituitary function return to normal except for hypothyroidism.

• Computed tomography (CT)
• histology
• magnetic resonance (MR)
• sellar chondroma
• transsphenoidal approach

Acknowledgments

We thank Feiyan Chen for providing cryoconserved tissue from patients.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

This work was supported by the Department of Pathology of the Second Hospital of Anhui Medical University.

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Notes

*Lubin Qiu and Yongjun Zhu contributed equally to this work.