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Original Article

Immunological abnormalities in opsoclonus cerebellopathy

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Pages 271-275 | Accepted 24 May 1985, Published online: 08 Jul 2009
 

Abstract

Opsoclonus and other cerebellar symptomatology developed in a patient who underwent mastectomy for adenocarcinoma of the breast. No evidence for metastases was found. Immunological studies demonstrated decreased function of T suppressor cells and hyperreactivity of T helper cells in spite of a normal suppressor/ helper ratio. The clinical condition, as well as the immunological abnormalities normalized under steroid treatment. An autoimmune process as etiopathogenesis of this paraneoplastic syndrome is proposed.

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