Cortical blindness and occipital lobe seizures induced by cis-platinum

Jorge c. Kattah Departments of Neurology, Obstetrics and Gynecology, Medicine, Vincent T. Lombardi Cancer Research Center, Georgetown University Hospital, Washington, DC, USA

Samuel J. Potolicchio Departments of Neurology, Obstetrics and Gynecology, Medicine, Vincent T. Lombardi Cancer Research Center, Georgetown University Hospital, Washington, DC, USA

Herbert L. Kotz Departments of Neurology, Obstetrics and Gynecology, Medicine, Vincent T. Lombardi Cancer Research Center, Georgetown University Hospital, Washington, DC, USA

Martin P. Kolsky Departments of Neurology, Obstetrics and Gynecology, Medicine, Vincent T. Lombardi Cancer Research Center, Georgetown University Hospital, Washington, DC, USA

David Thomas Departments of Neurology, Obstetrics and Gynecology, Medicine, Vincent T. Lombardi Cancer Research Center, Georgetown University Hospital, Washington, DC, USA

Abstract

Three patients developed occipital lobe seizures as a manifestation of diaminodichloro platinum (DDP) toxicity. They were characterized in two patients by cortical blindness, ictal nystagmus and a confusional state. The third patient had visual hallucinations followed by grand mal seizures. All the abnormalities in these patients responded to anticonvulsant therapy.

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Cortical blindness and occipital lobe seizures induced by cis-platinum

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Cortical blindness and occipital lobe seizures induced by cis-platinum

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