Myeloma-Associated Orbital Amyloidosis

Abstract

Orbital amyloidosis is extremely rare and may be localized finding or secondary to a systematic process. The majority of the patients with orbital amyloidosis have primary localized disease. We report a 55 year old male with multiple myeloma and secondary amyloidosis who presented with incidental bilateral orbital masses on MRI. Biopsy revealed amyloid deposition. We review the previously published cases of the orbital amyloidosis secondary to systematic light chain (AL) amyloidosis, including one patient with multiple myeloma. The clinical signs and symptoms, histopathologic findings, and radiographic features of orbital amyloidosis are discussed.

KEYWORDS::

• Orbital amyloidosis
• Myeloma-associated amyloidisis

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.