Effect of a Synthetic Leukocyte Elastase Inhibitor on Thrombin-Induced Pulmonary Edema in the Rat

Chul Min Ahn Department of Internal Medicine, Yongsei University College of Medicine, Youngdong, P.O. Box 1217, Seoul Korea; Department of Forensic Medicine, University of Uppsala, Sweden; ICI Americas Inc., Wilmington, DE; Department of Forensic Medicine, University of Uppsala, Sweden

Hakan Sandler Department of Internal Medicine, Yongsei University College of Medicine, Youngdong, P.O. Box 1217, Seoul Korea; Department of Forensic Medicine, University of Uppsala, Sweden; ICI Americas Inc., Wilmington, DE; Department of Forensic Medicine, University of Uppsala, Sweden

Mitchell Glass Department of Internal Medicine, Yongsei University College of Medicine, Youngdong, P.O. Box 1217, Seoul Korea; Department of Forensic Medicine, University of Uppsala, Sweden; ICI Americas Inc., Wilmington, DE; Department of Forensic Medicine, University of Uppsala, Sweden

Tom Saldeen Department of Internal Medicine, Yongsei University College of Medicine, Youngdong, P.O. Box 1217, Seoul Korea; Department of Forensic Medicine, University of Uppsala, Sweden; ICI Americas Inc., Wilmington, DE; Department of Forensic Medicine, University of Uppsala, Sweden

Abstract

The effect of a synthetic leukocyte elastase inhibitor on thrombin-induced pulmonary edema was studied in rats. The chloromethylketone human neutrophil elastase inhibitor, ICI 200,355, blunted rat leukocyte elastase activity in rat lung tissue. Administration of thrombin produced a significant increase (p < .01) in lung weight. The wet weight to dry weight ratio (WW/DW) and relative water contents were also significantly elevated (p < .01). Pretreatment with ICI 200,355 (200 μg/kg h⁻¹) resulted in significant reductions (p < .05) in lung weight and a tendency to decrease WW/DW and water content compared with animals given thrombin alone. It is possible that the elastase inhibitor effectively reduced the rate of thrombin-induced pulmonary edema by attenuation of increased vascular permeability.

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Effect of a Synthetic Leukocyte Elastase Inhibitor on Thrombin-Induced Pulmonary Edema in the Rat

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Effect of a Synthetic Leukocyte Elastase Inhibitor on Thrombin-Induced Pulmonary Edema in the Rat

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