Cytoskeleton Remodeling and Oxidative Stress Description in Morphologic Changes of Chondrocyte in Kashin–Beck Disease

Abstract

Kashin–Beck disease (KBD) is a kind of deformity disease involved in cytoskeleton and inner homeostasis regulation. The enrichment analysis of bioprocess, networks, and related disease set were performed. The development regulation, metabolic process, and apoptosis were important procession in KBD; it revealed the up-regulated process in removal of superoxide radicals, glycolysis and glucose catabolic process, regulation of cytoskeleton rearrangement and phagosome in antigen presentation. Morphological changes of KBD chondrocyte were investigated by transmission electronic microscopy compare with the normal one. The ultrastructure of KBD chondrocyte referred to oxidative stress and metabolic dysfunction has been found.

• Kashin–Beck disease
• mitochondria
• endoplasmic reticulum
• biological information
• cytoskeleton
• oxidative stress

Acknowledgments

The authors thank all the doctors from Electric Microscopy Laboratory of Health Science Center of Xi'an Jiaotong University for specimen preparation and support and also thank bioinformatics center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.

Statement of author contributions

Wei Juan Ma conceived study design, data analysis, experiments, and writing of the manuscript. Xiong Guo conceived study design and writing of the manuscript. Yue Xiang Yu conceived the operation and specimen collection. Zong Qiang Gao conceived experiments. All authors had final approval of the submitted and published versions.