Origin and Significance of Intranuclear Tubular Inclusions in Type II Pulmonary Alveolar Epithelial Cells of Patients with Bleomycin and Busulfan Toxicity

F. Gyorkey Departments of Pathology, Pharmacology, and Virology, Baylor College of Medicine, 2002 Holcombe Boulevard, Houston, Texas, 77211; Department of Pathology, Veterans Administration Medical Center, 2002 Holcombe Boulevard, Houston, Texas, 77211

P. Gyorkey Baylor College of Medicine, Houston, Texas, 77211

J. G. Sinkovics Department of Medicine, The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston, Texas, 77030

Abstract

Abundant intranuclear tubular structures were observed in type II alveolar pneumocytes in lung biopsies from patients with bleomycin and busulfan toxicity. It is proposed that since chromatin-membrane interactions in eukaryotic cell nuclei do occur, the intranuclear proliferation of the tubular structures occurs as a result of the interaction of the drug with peri-chromatin.

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Origin and Significance of Intranuclear Tubular Inclusions in Type II Pulmonary Alveolar Epithelial Cells of Patients with Bleomycin and Busulfan Toxicity

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Origin and Significance of Intranuclear Tubular Inclusions in Type II Pulmonary Alveolar Epithelial Cells of Patients with Bleomycin and Busulfan Toxicity

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