Autologous Red Blood Cell and Platelet Engulfment in Hairy Cell Leukemia

Samuel P. Hammar Department of Pathology and the Section of Hematology-Oncology Seattle, Department of Internal Medicine, The Mason Clinic, Seattle, Washington, 98101

Dawn Bockus Department of Pathology and the Section of Hematology-Oncology Seattle, Department of Internal Medicine, The Mason Clinic, Seattle, Washington, 98101

Franque Remington Department of Pathology and the Section of Hematology-Oncology Seattle, Department of Internal Medicine, The Mason Clinic, Seattle, Washington, 98101

Keith Hallman Department of Pathology and the Section of Hematology-Oncology Seattle, Department of Internal Medicine, The Mason Clinic, Seattle, Washington, 98101

John W. Huff Department of Pathology and the Section of Hematology-Oncology Seattle, Department of Internal Medicine, The Mason Clinic, Seattle, Washington, 98101

Patrick A Ragen Department of Pathology and the Section of Hematology-Oncology Seattle, Department of Internal Medicine, The Mason Clinic, Seattle, Washington, 98101

Robert H. Rudolph Department of Pathology and the Section of Hematology-Oncology Seattle, Department of Internal Medicine, The Mason Clinic, Seattle, Washington, 98101

Albert B. Einstein Department of Pathology and the Section of Hematology-Oncology Seattle, Department of Internal Medicine, The Mason Clinic, Seattle, Washington, 98101

Jean Bell Department of Pathology and the Section of Hematology-Oncology Seattle, Department of Internal Medicine, The Mason Clinic, Seattle, Washington, 98101

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Abstract

Seven cases of hairy cell leukemia (leukemic reticulo-endotheliosis) are presented in which peripheral blood or splenic hairy cells or both were identified engulfing autologous red blood cells or platelets. In 3 patients, approximately 5-15% of their peripheral blood hairy cells were engulfing red cells and platelets. In 2 patients, intercellular junctions were present between processes of hairy cells and were similar to processes occasionally seen connecting Langerhans cells to each other. Also, parallel tubular arrays were identified in the cytoplasm of hairy cells from 2 other patients. We conclude that autologous red blood cell and platelet engulfment is a common finding in hairy cell leukemia.

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Autologous Red Blood Cell and Platelet Engulfment in Hairy Cell Leukemia

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Autologous Red Blood Cell and Platelet Engulfment in Hairy Cell Leukemia

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