Prognostic Relevance of Silver-Stained Nucleolar Proteins in Sarcomatoid Carcinomas of the Breast

Vincenzo Eusebi Institute of Anatomic Pathology, University of Bologna, Italy

Maria G. Cattani Institute of Anatomic Pathology, University of Bologna, Italy

Janez Lamovec Institute of Oncology, Ljubljana, Yugoslavia

Davide Treré Department of Experimental Pathology, University of Bologna, Italy

Claudio Ceccarelli Institute of Anatomic Pathology, University of Bologna, Italy

Paolo Veronesi National Cancer Institute, Milan, Italy

Claudio Clemente National Cancer Institute, Milan, Italy

Massimo Derenzini Department of Experimental Pathology, University of Bologna, Italy

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Abstract

Fourteen cases of sarcomatoid carcinomas of breast were evaluated by means of a silver technique that selectively stains proteins located in the nucleolar organizer regions (Ag-NORs). The mean area of Ag-NORs (MNORA) was in each case quantitatively analyzed by means of an automated image analyzer. Patients who died early of the disease had a higher MNORA than patients who survived longer than 3 years. The difference was statistically significant. Ag-NORs might be a novel parameter of prognostic relevance in specific cases.

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Prognostic Relevance of Silver-Stained Nucleolar Proteins in Sarcomatoid Carcinomas of the Breast

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Prognostic Relevance of Silver-Stained Nucleolar Proteins in Sarcomatoid Carcinomas of the Breast

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