Induction of Tubuloreticular Structures in Cultured Human Endothelial Cells by Recombinant Interferon Alfa and Beta

Samuel P. Hammar Diagnostic Specialties Laboratory, 700 Lebo Boulevard, Bremerton, Washington, 98310, USA; Virginia Mason Research Center Seattle, Washington, USA

Jenyung Luu Diagnostic Specialties Laboratory, 700 Lebo Boulevard, Bremerton, Washington, 98310, USA; Virginia Mason Research Center Seattle, Washington, USA

Dawn E. Bockus Diagnostic Specialties Laboratory, 700 Lebo Boulevard, Bremerton, Washington, 98310, USA; Virginia Mason Research Center Seattle, Washington, USA

Franque L. Remington Diagnostic Specialties Laboratory, 700 Lebo Boulevard, Bremerton, Washington, 98310, USA; Virginia Mason Research Center Seattle, Washington, USA

Jenwei Luu Diagnostic Specialties Laboratory, 700 Lebo Boulevard, Bremerton, Washington, 98310, USA; Virginia Mason Research Center Seattle, Washington, USA

Susan Friedman Diagnostic Specialties Laboratory, 700 Lebo Boulevard, Bremerton, Washington, 98310, USA; Virginia Mason Research Center Seattle, Washington, USA

Michael A. Bean Diagnostic Specialties Laboratory, 700 Lebo Boulevard, Bremerton, Washington, 98310, USA; Virginia Mason Research Center Seattle, Washington, USA

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Abstract

Tubuloreticular structures were induced in human umbilical vein endothelial cells cultured in media containing recombinant interferon alfa and beta but not in media containing recombinant interferon gamma or other agents that induce interferon, such as 5-bromodeoxyuridine or polyinosinic-polycytidylic acid. Recombinant interferon beta induced tubuloreticular structures in endothelial cells at a lower concentration and in a greater percentage of cell sections than recombinant interferon alfa. This report of tubuloreticular structures being induced in vitro in nonlymphoid cells provides evidence that interferon is the substance that causes the formation of tubuloreticular structures in endothelial cells in vivo.

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Induction of Tubuloreticular Structures in Cultured Human Endothelial Cells by Recombinant Interferon Alfa and Beta

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Induction of Tubuloreticular Structures in Cultured Human Endothelial Cells by Recombinant Interferon Alfa and Beta

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