Preparation and characterization of Vitamin-12 loaded biodegradable pH-sensitive microgels

Xu Xu State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Chengdu, PR China

ShaoZhi Fu State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Chengdu, PR China

Ke Wang State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Chengdu, PR China

WenJuan Jia College of Material Science and Engineering, Sichuan University, Chengdu, PR China

Gang Guo State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Chengdu, PR China

XiuLing Zheng State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Chengdu, PR China

PengWei Dong State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Chengdu, PR China

QingFa Guo State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Chengdu, PR China

ZhiYong Qian State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Chengdu, PR ChinaCorrespondence[email protected] [email protected]

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Abstract

This paper prepared novel biodegradable and pH-sensitive microgels based on Poly(ε-caprolactone)-Pluronic-Poly(ε-caprolactone)-dimethacrylate (PCFC-DMA), Poly(ethylene glycol) dimethacrylate (PEG-DMA) and methylacrylic acid (MAA) cross-linked with N,N’-methylenebisacrylamide (BIS), initiated by NaHSO₃, K₂S₂O₈. The blank microgels were prepared by inversed-phase suspension polymerization method and pH sensitivity of microgels was characterized. Then the blank microgels were loaded with hydrophilic model drug vitamin-12 (VB-12) and in vitro drug release behaviour was also studied here.

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Preparation and characterization of Vitamin-12 loaded biodegradable pH-sensitive microgels

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Preparation and characterization of Vitamin-12 loaded biodegradable pH-sensitive microgels

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