Chitosan nanoparticles as adenosine carriers

Mehdi Kazemzadeh-NarbatDepartment of Process Engineering and Applied Science, Dalhousie University, Halifax, Canada, ;Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA, and ;Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USACorrespondence[email protected]

Marla ReidDepartment of Process Engineering and Applied Science, Dalhousie University, Halifax, Canada,

Marianne Su-Ling BrooksDepartment of Process Engineering and Applied Science, Dalhousie University, Halifax, Canada,

Amyl GhanemDepartment of Process Engineering and Applied Science, Dalhousie University, Halifax, Canada,

Abstract

The objective of this research project was to evaluate the potential use of chitosan (CS) nanoparticles (NPs) as a drug delivery system for the molecule adenosine. Adenosine is an essential drug used for treating several health issues especially irregular heart rhythm. However, due to its extremely short half-life in vivo (<10 s), the effective delivery of adenosine in clinical applications is a significant challenge. In this research, adenosine was encapsulated into NPs formed by ionic gelation of CS. The encapsulation efficiency and loading capacity of 20% and 3% were obtained, respectively, by forming a complex between CS NPs and adenosine. The obtained CS NPs had a spherical shape in the size range of 260.6 ± 20.1 nm. Spectrophotometry analysis of the adenosine released in vitro showed an initial burst release phase, a plateau phase, followed by a steady release over a week.

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Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.

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Chitosan nanoparticles as adenosine carriers

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Chitosan nanoparticles as adenosine carriers

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