Preparation of magnetic and pH-responsive chitosan microcapsules via sonochemical method

Fengzhi XuCollege of Chemistry, Jilin University, Changchun, P. R. China;

Tianqi ZhaoCollege of Chemistry, Jilin University, Changchun, P. R. China;

Shurong WangDepartment of Ophthalmology, The Second Hospital of Jilin University, Changchun, P. R. China

Songfeng LiuCollege of Chemistry, Jilin University, Changchun, P. R. China;

Ting YangCollege of Chemistry, Jilin University, Changchun, P. R. China;

Zhanfeng LiCollege of Chemistry, Jilin University, Changchun, P. R. China;

Hongyan WangCollege of Chemistry, Jilin University, Changchun, P. R. China;

Xuejun CuiCollege of Chemistry, Jilin University, Changchun, P. R. China; Correspondence[email protected]

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Abstract

Magnetic and pH-responsive chitosan microcapsules (MPRCMCs) were prepared by a simple sonochemical method. Superparamagnetic oleic acid modified Fe₃O₄ nanoparticles (OA-Fe₃O₄ NPs) and hydrophobic drugs could be directly loaded into MPRCMCs during sonication. The obtained microcapsules had a well-defined spherical morphology with the average size of 2 μm. The microcapsules showed an excellent magnetic property. In addition, the pH-responsive controlled release of coumarin 6 (C6) from MPRCMCs indicated that the developed microcapsules could be a promising candidate for drugs carriers.

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Preparation of magnetic and pH-responsive chitosan microcapsules via sonochemical method

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Preparation of magnetic and pH-responsive chitosan microcapsules via sonochemical method

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