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Research Article

Dissolution studies of microencapsulated indomethacin; effect of method and medium on dissolution

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Pages 47-51 | Received 22 Oct 1983, Accepted 08 Nov 1983, Published online: 27 Sep 2008
 

Abstract

In vitro dissolution studies of microencapsulated indomethacin showed that the USP paddle method was superior to the USP basket method in that the drug release was higher and more uniform with the paddle. Simulated intestinal fluid (pH 7.2) was an appropriate medium to use for dissolution studies on prolonged-release microcapsules.

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