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Research Article

The preparation and characterization of ethyl cellulose-walled theophylline microcapsules

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Pages 53-64 | Received 10 Oct 1983, Accepted 06 Nov 1983, Published online: 27 Sep 2008
 

Abstract

The use of sustained-release preparations of theophylline has become routine in the treatment of bronchial asthma. Microencapsulation provides a possible means of producing such a product. The present paper examines, by means of triangular diagrams, the phases present in the system ethylcellulose-petroleum ether-toluene. The separated cellulose was used to coat the drug theophylline. The effects of temperature, petroleum ether fraction, solvent: non-solvent ratio and rate of non-solvent addition on the size and size distribution of the microcapsules was studied.

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