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Research Article

Electron microscopical study of the structure of liposome-type artificial red blood cells stabilized with carboxymethylchitin

, , , &
Pages 329-333 | Received 07 Aug 1984, Accepted 11 Sep 1984, Published online: 27 Sep 2008
 

Abstract

Stable liposome-type artificial red blood cells containing either an aqueous bromothymol solution or erythrocyte haemolysate were produced using carboxymethylchitin as a stabilizer. The structure of the resulting vesicles was investigated by electron microscopy after freeze-fracturing, freeze-substitution and negative staining. The vesicles were not homogeneous but contained unilamellar and multilamellar structures. The maximum size was about 2μm; most vesicles were about 200–500 nm in size. The carboxymethylchitin did not yield a continuous layer but rather occurred in patches on the membrane surface probably forming a mesh-like layer over the entire liposome surface.

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