Toxicity and association of polycyanoacrylate nanoparticles with hepatocytes

J. Kreuter Department of Pharmaceutics, Swiss Federal Institute of Technology ETH, Zurich, Switzerland

C. G. Wilson Department of Physiology & Pharmacology, Queen's Medical Centre, Nottingham, England

J. R. Fry Department of Physiology & Pharmacology, Queen's Medical Centre, Nottingham, England

P. Paterson Department of Physiology & Pharmacology, Queen's Medical Centre, Nottingham, England

J. H. Ratcliffe Department of Physiology & Pharmacology, Queen's Medical Centre, Nottingham, England

Abstract

The degradation of polybutylcyanoacrylate (PBC) and polyhexylcyanoacrylate (PHC) nanoparticles, together with their association with and toxicity towards isolated hepatocytes, were determined. Nanoparticles were not taken up by rat hepatocytes at a significant level. The LD₅₀s of PBC and PHC nanoparticles towards hepatocytes were 0.4mg/2 × 10⁶ cells and >1 mg/2 × 10⁶ cells respectively. This hepatocyte toxicity cannot be attributed solely to the formaldehyde formed during degradation.

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Toxicity and association of polycyanoacrylate nanoparticles with hepatocytes

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Toxicity and association of polycyanoacrylate nanoparticles with hepatocytes

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