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Research Article

Dissolution studies of microencapsulated 4-sulphonamidophenoxyacetic acid: effect of preparative variables on dissolution

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Pages 223-234 | Received 10 Jul 1985, Accepted 19 Jul 1985, Published online: 27 Sep 2008
 

Abstract

Ethylcellulose-walled microcapsules of 4-sulphonamidophenoxyacetic acid were prepared and their in vitro dissolution characteristics were investigated. Different release kinetics must be applied according to the respective average particle size and wall content values of the microcapsule fractions. The ‘dissolution model’ appears to fit better with small thin-walled microcapsules whereas, for larger thicker-walled microcapsules, Higuchi-type kinetics seem to describe the release of the major part of the drug more adequately.

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