Aggregation of unilamellar lecithin liposomes induced by cyclosporin

Abstract

Small unilamellar [¹⁴C]lecithin liposomes prepared in the presence of cyclosporin sedimented at 12000 g. Sepharose 4B gel filtration of the resuspended pellet and supernatant yielded identical peaks consisting of small unilamellar liposomes containing cyclosporin. The column retained 40–50 per cent of ¹⁴C-labelled liposomes prepared in the presence of cyclosporin as liposome aggregates.