Studies on zinc sulphate microcapsules (1): Microencapsulation and in vitro dissolution kinetics

Abstract

Microcapsules of zinc sulphate with core: wall ratios of 1:1 and 2:1 were prepared by the coacervation method, using ethylcellulose as the coating material. The prepared microcapsules were separated into batches of 250 and 500 μm in size by sieving. The effects of particle size, the amount of zinc sulphate, and the core: wall ratio on the dissolution kinetics were studied, and evaluated kinetically by the Rosin-Rammler-Sperling-Bennet-Weillbull (RRSBW) distribution.