Preparation and characterization of indomethacin magnetic nanoparticles

Abstract

Nanoparticles of polymethylmethacrylate were prepared by the emulsion polymerization technique. The drug was embedded in the nanoparticles. The controlled growth of ferric hydroxide particles in the presence of non-ionic surfactant was effected to obtain nano-size particles and these were subsequently heated to obtain ferroso-ferric oxide (magnetite). The effect of various parameters, i.e. monomer concentration and magnetite concentration, as well as the stirring rate were studied to characterize the particle size and its distribution. Similarly, the factors which affect the total drug payload were assessed. The magno-responsive indomethacin nanoparticles were successfully prepared.