In Vivo Characterization of Indomethacin Magnetic Polymethyl Methacrylate Nanoparticles

Abstract

The in vivo magnet responsiveness and kinetics of distribution of indomethacin entrapped in a magnetic and plain carrier were characterized by rat tail model and periodic monitoring of drug concentration in various visceral organs after intraarterial and intravenous administration respectively. Up to 60 min post injection time 60-fold higher concentrations could be achieved in tail target segment which resulted in considerably reduced drug concentration in other organs as evinced by data from control rats. Following normal administration (no magnetic field applied) the drug concentration was higher in the liver and spleen where cndocytosis and phagocytosis occur. The magnetic nanoparticle of indomethacin holds promise for selective targeting under magnetic field of 8000 Oe strength.