Selective transfer of cyclosporin to thoracic lymphatic systems by the application of lipid microspheres

Akira Yanagawa First Department of Internal Medicine, School of Medicine, St. Marianna University, 2-16-1 Sugao, Miyamae-ku, Kawasaki-city, Kanagawa-Pref 213Japan

Takashi Iwayama First Department of Internal Medicine, School of Medicine, St. Marianna University, 2-16-1 Sugao, Miyamae-ku, Kawasaki-city, Kanagawa-Pref 213Japan

Tomoko Saotome First Department of Internal Medicine, School of Medicine, St. Marianna University, 2-16-1 Sugao, Miyamae-ku, Kawasaki-city, Kanagawa-Pref 213Japan

Yoko Shoji First Department of Internal Medicine, School of Medicine, St. Marianna University, 2-16-1 Sugao, Miyamae-ku, Kawasaki-city, Kanagawa-Pref 213Japan

Keiyu Takano First Department of Internal Medicine, School of Medicine, St. Marianna University, 2-16-1 Sugao, Miyamae-ku, Kawasaki-city, Kanagawa-Pref 213Japan

Hiroshi Oka First Department of Internal Medicine, School of Medicine, St. Marianna University, 2-16-1 Sugao, Miyamae-ku, Kawasaki-city, Kanagawa-Pref 213Japan

Takemasa Nakagawa First Department of Internal Medicine, School of Medicine, St. Marianna University, 2-16-1 Sugao, Miyamae-ku, Kawasaki-city, Kanagawa-Pref 213Japan

Yutaka Mizushima First Department of Internal Medicine, School of Medicine, St. Marianna University, 2-16-1 Sugao, Miyamae-ku, Kawasaki-city, Kanagawa-Pref 213Japan

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Abstract

To overcome some of the disadvantages of present cyclosporin A (CsA) therapy, lipid microspheres incorporating CsA (lipo-CsA) were designed and their selective transfer to thoracic lymphatic systems was evaluated in vivo. It was found that concentrations of CsA in lymph-ducts were about 46 times higher after 2h and 9-10 times higher after 3h following oral administration of lipo-CsA, compared with those of conventional CsA. The concentrations in plasma produced by lipo-CsA were also higher than those produced by conventional CsA.

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Selective transfer of cyclosporin to thoracic lymphatic systems by the application of lipid microspheres

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Selective transfer of cyclosporin to thoracic lymphatic systems by the application of lipid microspheres

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