Liposomes as Cyclosporin a Carriers: Positively Charged Lecithin-Cholesterol Liposomes Associated with Cyclosporin a do not Inhibit Biosynthesis of Mitochondrial Poly Glycerophosphates and Microsomal Phosphatidylinositol

Lidija Stuhne-Sekalec The Department of Clinical Biochemistry, Banting Institute, Faculty of Medicine, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, M5G 1L5, Canada

Nikola Z. Stanacev The Department of Clinical Biochemistry, Banting Institute, Faculty of Medicine, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, M5G 1L5, Canada

Abstract

Phosphatidylcholine (from egg yolk)-cholesterol-stearylamine (7:2:2-25, molar ratio) liposomes when associated with cyclosporin A (phosphatidylcholine: cyclosporin A = 2.007, molar ratio) do not inhibit significantly the biosynthesis of [³H]polyglycerophosphatides and [³H]phosphatidylinositol in mitochondrial and microsomal membranes, respectively, isolated from rat liver. These results are explained by possible protection of the liposomes by cyclosporin A against phospholipase A₂ hydrolysis.

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Liposomes as Cyclosporin a Carriers: Positively Charged Lecithin-Cholesterol Liposomes Associated with Cyclosporin a do not Inhibit Biosynthesis of Mitochondrial Poly Glycerophosphates and Microsomal Phosphatidylinositol

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Liposomes as Cyclosporin a Carriers: Positively Charged Lecithin-Cholesterol Liposomes Associated with Cyclosporin a do not Inhibit Biosynthesis of Mitochondrial Poly Glycerophosphates and Microsomal Phosphatidylinositol

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