Inhibition of liposomal lipid peroxidation by spermidine

Abstract

Spermidine was found to inhibit the in vitro formation of thiobarbituric acid-reactive material from sonicated vesicles of rat brain and individual phospholipids, especially in the presence of externally added iron. With arachidonic acid incorporated liposomes spermidine inhibited lipid peroxidation in the presence or the absence of Fe²⁺, to similar extent. Thus spermidine inhibition of lipid peroxidation may not be entirely iron-dependent.