Microencapsulation of propranolol hydrochloride by the solvent evaporation technique

Abstract

Propranolol hydrochloride microcapsules were prepared by the coacervationphase separation induced by solvent evaporation technique. The cellulose acetate phthalate was employed as coating material alone and in combination with ethyl cellulose. The prepared microcapsules were evaluated for their drug content, particle size distribution (microscopic method), flow properties, bulk density, in vitro dissolution and drug release kinetics.