Decrease in the placental transfer of chloramphenicol when administered in albumin microspheres into rats

M. A. Onur Hacettepe University, Department of Biology, Beytepe, 06532, Ankara, Turkey

I. Vurai Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06100, Ankara, Turkey

H. S. Kaα Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06100, Ankara, Turkey

A. A. Hincal Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06100, Ankara, Turkey

T. Coskun Hacettepe University, Department of Biology, Beytepe, 06532, Ankara, Turkey

G. Kanra Hacettepe University, Faculty of Medicine, Department of Pediatrics, 06100, Ankara, Turkey

A. Tümer Hacettepe University, Department of Biology, Beytepe, 06532, Ankara, Turkey

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Abstract

Chloramphenicol is an antibiotic which can pass across the human placenta and has teratogenic effects in the foetus. When this antibiotic is entrapped in albumin microspheres and administered to pregnant rats intravenously its placental transport is significantly lowered when compared with that of free drug. Drug modifications such as entrapment are suggested as an alternative way to prevent harmful effects of drugs in case of consumption during pregnancy.

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Decrease in the placental transfer of chloramphenicol when administered in albumin microspheres into rats

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Decrease in the placental transfer of chloramphenicol when administered in albumin microspheres into rats

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