Sustained-release dosage form of phenylpropanolamine hydrochloride. Part I: Microencapsulation and in vitro release kinetics

Abstract

Microcapsules of phenylpropanolamine hydrochloride with core : wall ratios of 1: 1,2: 1 and 1 : 2 were prepared by the coacervation-phase separation method, using ethylcellulose as the coating material. Two batches of PPA.HC1 powder with different particle sizes (< 58µm and > 28µm) were used as the core material. The different sizes of microcapsules were separated using a range of standard sieves (840-247µm). The effects of drug particle size, the media pH and the core: wall ratio on the dissolution kinetics were studied, and evaluated kinetically.