Abstract
This work was planned to prepare sustained-action preparations of phenylpropanolamine hydrochloride by microencapsulation and by tableted microcapsules. Dissolution from both suspended microcapsules and the tablets was studied using the USP XXII basket method in simulated gastric and intestinal fluid without enzyme. The results were applied to zero-order, first-order, Hixson Crowell, RRSBW, Q/✓t, (Bt)a and Higuchi kinetic models. Dissolution of PPA.HC1 was found to be governed by the core: wall ratio, drug particle size, media pH and type of disintegrating agent. Dissolution kinetics were studied and evaluated.