Cellulose acetate butyrate microparticles for controlled release of carbamazepine

Abstract

Cellulose acetate butyrate microparticles loaded in carbamazepine were prepared by a solvent evaporation technique. A decrease of the amount of organic solvent (from 80 to 40 ml of methylene chloride) increased the microparticle average diameter (73–111 and 207 μm) and decreased the carbamazepine release rate (T₅₀% increased from 3·3 to 16·8 and 166·4 min). The microparticle area under the curve at 120 min was similar to that obtained with Tegretol LP® 200 tablets.

Key Words:

• Microparticles
• cellulose acetate butyrate
• carbamazepine
• solvent evaporation
• controlled release