Altered interhemispheric resting state functional connectivity during passive hyperthermia

Abstract

Purpose: This study examines the effect of passive hyperthermia on interhemispheric resting state functional connectivity and the correlation between interhemispheric resting state functional connectivity and efficiency of a succedent working memory task. Materials and methods: We performed voxel-mirrored homotopic connectivity (VMHC) analyses on resting state MRI data and a one-back task from 14 healthy subjects in both HT (hyperthermia, 50 °C) conditions and normal control (NC, 25 °C) conditions. The group analyses of the differences for VMHC between the two conditions and the correlation analysis between the VMHC and the reaction time (RT) of the one-back task were performed with the statistical parametric mapping software package and the software REST. Results: Compared with NC conditions, HT conditions increased VMHC in the cuneus, the postcentral gyrus, and the fusiform gyrus. No region showed decreased VMHC in the HT group in comparison with the NC group. For NC conditions, negative correlations were demonstrated between RT of the one-back task and VMHC in bilateral superior temporal gyrus, and bilateral middle frontal gyrus; for HT conditions, negative correlations were demonstrated between RT and VMHC in bilateral inferior frontal gyrus, bilateral middle frontal gyrus, as well as cerebellum posterior lobe. Conclusion: Passive heat stress can impact the interhemispheric information interactions at resting state and the VMHC deficits may play an important role in cognitive dysfunction.

• Passive hyperthermia
• resting state
• voxel-mirrored homotopic connectivity
• working memory
• functional MRI

Declaration of interest

The authors report no conflicts of interest. The authors thank all the participants for their time in completing the tasks. The authors alone are responsible for the content and writing of the paper.

This work was supported by the China Postdoctoral Science Foundation (no. 2014M552596).