Sensitivities of bleomycin-resistant variant cells enhanced by 40°C hyperthermia in vitro

Eiichi Kano Department of Experimental Radiology and Health physics, Fukui Medical University, Matsuoka, Fukui, 910-11, Japan

Masayo Furukawa-furuya Department of Experimental Radiology and Health physics, Fukui Medical University, Matsuoka, Fukui, 910-11, Japan

Kazumi Nitta Department of Experimental Radiology and Health physics, Fukui Medical University, Matsuoka, Fukui, 910-11, Japan

Tomoko Kajimoto-kinoshita Department of Radiation Biology, Kyoto College of Pharmacy, Yamashina, Kyoto, 607, Japan

Porntipa Picha Research Division, National Cancer Institute, Bangkok, 10400, Thailand

Kiyoshi Sugimoto Department of Radiology, Osaka City, University School of Medicine, Abeno, Osaka, 545, Japan

Toshio Ohtsubo Department of Experimental Radiology and Health physics, Fukui Medical University, Matsuoka, Fukui, 910-11, Japan

Koh Tsuji Department of Experimental Radiology and Health physics, Fukui Medical University, Matsuoka, Fukui, 910-11, Japan

Susumu Tsubouchi Department of Experimental Radiology and Health physics, Fukui Medical University, Matsuoka, Fukui, 910-11, Japan

Takashi Kondo Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA

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Abstract

Cultured mammalian cells of higher (mouse L) and lower (Chinese hamster V-79) sensitivities to bleomycin (BLM) were repeatedly treated with BLM (0.1 mg/ml), through which BLM-resistant variant strains were induced. Sensitivities of these variant strains to BLM were enhanced by simultaneous treatment with 40°C hyperthermia.

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Sensitivities of bleomycin-resistant variant cells enhanced by 40°C hyperthermia in vitro

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Sensitivities of bleomycin-resistant variant cells enhanced by 40°C hyperthermia in vitro

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