Effects of cis-diamminedichloroplatinum (CDDP) and cis-diammine (1,1-cyclobutanedicarboxylate) platinum (CBDCA) on thermotolerance development and thermosensitivity of the thermotolerant cells

Abstract

The interactive effects of combined treatment with heat and CDDP (0·5 μg/ml) or CBDCA (10 μg/ml) were examined on the surviving fractions of V-79 cells. Both CDDP and CBDCA treatment induced a slight enhancement in thermosensitivity of thermotolerant cells. The development of thermotolerance during step-up heating was partially inhibited by simultaneous treatment with CDDP or CBDCA throughout the heating process. Simultaneous heat treatment at 42°C with either drug showed marked interactive effect and inhibited the thermotolerance developed during 42°C heating.

Key Words:

• chemical thermoenhancement
• hyperthermic chemoenhancement
• thermochemotherapy
• in vitro cultured V-79 cell strain