Beta-blockade during whole-body hyperthermia: A toxicity study in the dog

H. Robins Departments of Human Oncology, School of Veterinary Medicine, University of Wisconsin Clinical Cancer Center, Clinical Science Center, Madison, Wisconsin, 53792, USA; Departments of Medicine and Medical Sciences, School of Veterinary Medicine, University of Wisconsin Clinical Cancer Center, Clinical Science Center, Madison, Wisconsin, 53792, USA

A. Hugander Departments of Human Oncology, School of Veterinary Medicine, University of Wisconsin Clinical Cancer Center, Clinical Science Center, Madison, Wisconsin, 53792, USA

M. Besozzi Departments of Medicine and Medical Sciences, School of Veterinary Medicine, University of Wisconsin Clinical Cancer Center, Clinical Science Center, Madison, Wisconsin, 53792, USA

C. L. Schmitt Departments of Human Oncology, School of Veterinary Medicine, University of Wisconsin Clinical Cancer Center, Clinical Science Center, Madison, Wisconsin, 53792, USA

P. A. Martin Departments of Human Oncology, School of Veterinary Medicine, University of Wisconsin Clinical Cancer Center, Clinical Science Center, Madison, Wisconsin, 53792, USA

L. V. Zager Departments of Medicine and Medical Sciences, School of Veterinary Medicine, University of Wisconsin Clinical Cancer Center, Clinical Science Center, Madison, Wisconsin, 53792, USA

J. Grossman Departments of Medicine and Medical Sciences, School of Veterinary Medicine, University of Wisconsin Clinical Cancer Center, Clinical Science Center, Madison, Wisconsin, 53792, USA

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Abstract

A radiant heat device (RHD) for whole-body hyperthermia (WBH) has been safely and effectively used with a dog model. The cardiovascular changes which occur in the dog during WBH—including heart rate, blood pressure, cardiac output, stroke volume and ejection fraction—agree qualitatively and quantitatively with changes observed in previous WBH-RHD studies done in pigs and humans. We elected to study the effect of propanolol in dogs during WBH in order to evaluate this drug's potential use in human cancer patients who are ineligible for WBH because of coronary artery disease. This report details cardiovascular changes which occur with β-blockade during 42°C WBH in the dog. Our results show that the level of β-blockade needed to control heart rate during WBH produces acute cardiovascular decompensation.

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Beta-blockade during whole-body hyperthermia: A toxicity study in the dog

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Beta-blockade during whole-body hyperthermia: A toxicity study in the dog

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