Effect of hyperthermia on the in vitro hydrolysis of melphalan

J. E. Riviere Cutanmus Pharmacology and Toxicology Center, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27606, USA

R. L. Page Cutanmus Pharmacology and Toxicology Center, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27606, USA

D. P. Aucoin Cutanmus Pharmacology and Toxicology Center, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27606, USA

R. A. Rogers Cutanmus Pharmacology and Toxicology Center, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27606, USA

P. L. Williams Cutanmus Pharmacology and Toxicology Center, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27606, USA

Abstract

The pharmacokinetics of melphalan was investigated at 37°C and 42°C in vitro in canine and porcine plasma to assess heat-induced changes in the in vivo rate of melphalan hydrolysis. Melphalan concentrations were assayed using HPLC. Rate of spontaneous hydrolysis of melphalan at 42°C was increased 1.5-fold in canine and 1.9-fold in porcine plasma. These results should be considered when interpreting in vivo disposition studies.

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Effect of hyperthermia on the in vitro hydrolysis of melphalan

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Effect of hyperthermia on the in vitro hydrolysis of melphalan

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