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International Journal of Hyperthermia Volume 8, 1992 - Issue 2
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Original Article

Encapsulated liquid crystals as probes for remote thermometry

K. J. Franklin AECL Research, Chalk River Laboratories, Chalk River, Ontario, KOJ 1JO, Canada
,
R. J. Buist MR Research Laboratory, Health Sciences Centre, Winnipeg, Manitoba, R3E 0W3, Canada
,
J. den Hartog AECL Research, Chalk River Laboratories, Chalk River, Ontario, KOJ 1JO, Canada
,
G. A. McRae AECL Research, Chalk River Laboratories, Chalk River, Ontario, KOJ 1JO, Canada
&
D. P. Spencer Duke University Medical Center, Durham, N Carolina, 27710, USA
Pages 253-262 | Received 18 Dec 1990, Accepted 04 Sep 1991, Published online: 09 Jul 2009
 
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Abstract

A temperature probe based on the magnetic resonance properties of an encapsulated liquid crystal has been investigated. Large changes in magnetic resonance signals occur as the liquid crystal undergoes a phase transition from an anisotropic (nematic) state to the isotropic liquid. The low latent heat of such phase transitions allows for rapid phase changes during a hyperthermia treatment. Transition temperatures can be tailored by adding suitable compounds such as analogues of the liquid crystal or various solvents. Encapsulation is required to maintain the integrity of the liquid crystal, particularly for applications in vivo. Results of preliminary studies designed to demonstrate the technical feasibility of the concept are presented.

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