On the accuracy of noninvasive thermometry using molecular diffusion magnetic resonance imaging

Y. Zhang Department of Electrical Engineering, Duke University, Durham, NC, 27706, USA

T. V. Samulski Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27710, USA

W. T. Joines Department of Electrical Engineering, Duke University, Durham, NC, 27706, USA

J. Mattiello Department of Biomedical Engineering and Instrumentation Program, National Institutes of Health, Bethesda, MD, 20892, USA

R. L. Levin Department of Biomedical Engineering and Instrumentation Program, National Institutes of Health, Bethesda, MD, 20892, USA

D. Lebihan Department of Diagnostic Radiology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, 20892, USA

Abstract

Temperature measurement using magnetic resonance imaging (MRI) of water self-diffusion is investigated. Diffusion images and derived temperatures are obtained in polyacrylamide gel phantom. The temperatures measured from MRI are compared with those from temperature probes to verify their accuracy. In general, the difference between temperatures determined from MRI diffusion images over 0·3 cm³ regions of interest and from temperature probes were 0 · 2°C. It is concluded that current MRI technology allows noninvasive temperature tomography that is comparable with invasive thermometry with respect to temperature accuracy, has spatial and time resolutions that would be useful in hyperthermic oncology.

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On the accuracy of noninvasive thermometry using molecular diffusion magnetic resonance imaging

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On the accuracy of noninvasive thermometry using molecular diffusion magnetic resonance imaging

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