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International Journal of Hyperthermia Volume 10, 1994 - Issue 1
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Original Article

Interaction of hyperthermia and chemotherapy agents; cell lethality and oncogenic potential

R. C. Miller Center for Radiological Research, College of Physicians and Surgeons of Columbia University, New York, NY, 10032, USA; Department of Radiation Oncology, St Barnabas Medical Center, Livingston, NJ, 07039, USA
,
M. Richards Center for Radiological Research, College of Physicians and Surgeons of Columbia University, New York, NY, 10032, USA
,
C. Baird Center for Radiological Research, College of Physicians and Surgeons of Columbia University, New York, NY, 10032, USA
,
S. Martin Center for Radiological Research, College of Physicians and Surgeons of Columbia University, New York, NY, 10032, USA
&
E. J. Hall Center for Radiological Research, College of Physicians and Surgeons of Columbia University, New York, NY, 10032, USA
Pages 89-99 | Received 28 Sep 1992, Accepted 19 May 1993, Published online: 09 Jul 2009
 
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Abstract

Hyperthermia was combined with bleomycin, melphalan and cis-platinum in order to examine cell lethality and oncogenic transformation in C3H10T1/2 cells from the adjuvant use of heat with chemotherapy agents. When cells were exposed concurrently to 42·5°C and each of the three chemotherapy agents, heat enhanced both the cytotoxic and oncogenic potential of the drugs. Hyperthermia-enhanced ratios were largest for bleomycin-treated cells. Examination of transformation incidences expressed as a function of surviving fraction, i.e. the cytotoxicity of treatment and therefore drug-heat efficacy, showed that for a given level of cell killing the combination of heat and cis-platinum resulted in fewer transformants per surviving cell than for cis-platinum alone. Hyperthermia appears to reduce the oncogenic potential of low concentrations of melphalan but has no effect on bleomycin-induced oncogenic transformation.

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