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Original Article

Mammalian cell survival studies characterizing multiport negative π-meson irradiation with the Stanford Medical Pion Generator (SMPG)

, , , , &
Pages 361-370 | Published online: 09 Jul 2009
 

Abstract

Radiobiological measurements have been made under various conditions of muliport pion irradiation using the Stanford Medical Pion Generator (SMPG). Chinese hamster cells (HA-1) were suspended in a tissue-equivalent 25% gelatin/medium solution. Hypoxic and aerobic HA-1 cells were irradiated simultaneously in a cylindrical water tank at either 4 or 16°C. Irradiation at the focus of 60 converging pion beams, at a peak dose rate of 6 rads/min, gave relative biological effectiveness (RBEs) of 2 · 8, 1 · 8 and 1 · 4 at 50, 20 and 5% survival, respectively, and an oxygen enhancement ratio (OER) of 1 · 7. Plateau irradiation with crossing pion beams, at a peak dose-rate of 3 rads/min, resulted in survival values very close to those obtained with similar doses of 85 kV X-rays. Preliminary studies with large irradiation volumes in broadened pion stopping regions indicate RBEs significantly > 1 for survival > 50%. Supporting microdosimetric data with the SMPG are consistent with the radiobiological results.

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