In-vivo NMR thermometry with liposomes containing ⁵⁹Co complexes

A. G. Webb Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, 1406 West Green StreetIllinois, 61801, USA

M. Wong School of Chemical Sciences, University of Illinois at Urbana-Champaign, Urbana, 1406 West Green Street, Illinois, 61801, USA

M. Niesman Department of Physiology and Biophysics, University of Illinois at Urbana-Champaign, Urbana, 1406 West Green Street, Illinois, 61801, USA

K. J. Kolbeck Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, 1406 West Green StreetIllinois, 61801, USA

L. J. Wilmess St. Louis University, Anheuser-Busch Eye Institute, St. Louis, Missouri, USA

R. L. Magin Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, 1406 West Green StreetIllinois, 61801, USA

K. S. Suslick School of Chemical Sciences, University of Illinois at Urbana-Champaign, Urbana, 1406 West Green Street, Illinois, 61801, USA

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Abstract

The ability to make localized temperature measurements in tissue during hyperthermia treatment of cancer is an essential factor in optimizing its efficacy. To this end we have developed and evaluated the complex tris(ethylenediamine) cobalt(III) trichloride as a temperature sensor by determining the temperature dependence of its ⁵⁹Co nuclear magnetic resonance chemical shift. Encapsulating this complex within liposomes targets the agent to the reticuloendothelial system. Temperature changes of the order of 0.1 °C have been measured in vivo on rats, and the half-life of the complex within the body determined by plasma emission spectroscopy.

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In-vivo NMR thermometry with liposomes containing 59Co complexes

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In-vivo NMR thermometry with liposomes containing ⁵⁹Co complexes