Mammalian cells adapted to growth at pH 67 have elevated HSP27 levels and are resistant to cisplatin

P. R. Wachsberger Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107, USA

J. Landry Centre de recherche en cancérologie de l'Université Laval, l'Hotel-Dieu de Québec, Québec, Canada, G1R 2J6

C. Storck Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107, USA

K. Davis Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107, USA

M. D. O'Hara Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107, USA

C. S. Owen Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, PA, 19107, USA

D. B. Leeper Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107, USA; Kimmel Cancer Institute, Kimmell Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA

R. A. Coss Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107, USA; Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA; Kimmel Cancer Institute, Kimmell Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA

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Abstract

HSP27 levels are elevated in two Chinese hamster cell lines and in a human melanoma cell line adapted to growth at pH 6.7. The level of HSP72 is elevated in the melanoma cell line but not in the hamster cell lines adapted to growth at pH 6.7. HSC73 levels are not elevated in any of the adapted cell lines. Low pH adapted cells from all cell lines are resistant to cisplatin. It is proposed that elevated HSP27 levels in low pH-adapted cells may play a role in resistance to hyperthermia and resistance to cisplatin.

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Mammalian cells adapted to growth at pH 67 have elevated HSP27 levels and are resistant to cisplatin

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Mammalian cells adapted to growth at pH 67 have elevated HSP27 levels and are resistant to cisplatin

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