The effects of artery occlusion on temperature homogeneity during hyperthermia in rabbit kidneys in vivo

Z. Q. Jia Division of Experimental Therapeutics, Ontario Cancer Institute

A. E. Worthington Division of Experimental Therapeutics, Ontario Cancer Institute; Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, Canada

R. P. Hill Division of Experimental Therapeutics, Ontario Cancer Institute; Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, Canada

J. W. Hunt Division of Experimental Therapeutics, Ontario Cancer Institute; Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, Canada

Abstract

To investigate the role of arterial occlusion on temperature homogeneity during hyperthermia for deep seated tissue, a renal hyperthermia animal model has been established using New Zealand white rabbits. The effects of ultrasound-induced renal hyperthermia, with or without continuous and intermittent renal artery occlusion, were compared and analysed. Both continuous and intermittent occlusion showed certain protection of surrounding tissue and demonstrated improved temperature homogeneity and heating efficiency. The benefits of continuous vs. intermittent occlusion are compared and discussed as well.

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The effects of artery occlusion on temperature homogeneity during hyperthermia in rabbit kidneys in vivo

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The effects of artery occlusion on temperature homogeneity during hyperthermia in rabbit kidneys in vivo

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