Multiple schwannomatosis caused by the recently described INI1 gene – molecular pathology, and implications for prognosis

Abstract

The most common genetic predisposition to multiple schwannoma growth is mutation of the neurofibromatosis type 2 gene. We describe a patient with multiple schwannomas and mutation in the recently described INI1 gene, which also predisposes to the disease. We explore the implications for prognosis and outcome.

Key word:

• Schwanomma
• neurilemmoma
• NF2
• multiple

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.