Metastatic pancreatic neuroendocrine tumor to the central nervous system in a patient with von Hippel–Lindau disease: A case report and literature review

Abstract

Pancreatic neuroendocrine tumor (NET) is frequently encountered in patients with von Hippel–Lindau disease (VHL) and uncommonly metastasizes to the central nervous system. Here, we present the case of a VHL patient with symptomatic pancreatic NET metastases to both the cervical spinal cord and a preexisting brainstem hemangioblastoma (e.g., tumor- to-tumor metastasis).

Keywords::

• pancreatic neuroendocrine tumor
• tumor-to-tumor metastasis
• von Hippel–Lindau

Declaration of interest: The authors report no declarations of interest. The authors alone are responsible for the content.