Brain tumours and the occurrence of severe invasive basal cell carcinoma in first degree relatives with Gorlin syndrome

Abstract

We describe the occurrence of a medulloblastoma and an astrocytoma in successive generations of a family with the Gorlin syndrome. The appearance of thousands of invasive basal cell carcinomata after craniospinal irradiation led to the death of one patient from intracranial involvement.

Key Words:

• Basal cell carcinoma
• Gorlin syndrome
• medulloblastoma
• radiotherapy