368
Views
10
CrossRef citations to date
0
Altmetric
Research Article

The impact of S100b and persistent high levels of neuron-specific enolase on cognitive performance in elderly patients after cardiopulmonary bypass

&
Pages 417-424 | Received 26 Mar 2012, Accepted 14 Nov 2012, Published online: 08 Mar 2013
 

Abstract

Primary objectives: The primary aim was to investigate the impact of neuron-specific enolase (NSE) and S100 calcium-binding protein B (S100b) on cognitive functioning after cardiopulmonary bypass (CPB).

Research design: Prospective exploratory study.

Setting: Psychiatric Consultation-Liaison Service, Ludwig-Maximilians-University Medical School, Munich, Germany.

Participants: Thirty-four patients who underwent elective CPB.

Measurements: Before the CPB and on the day before discharge neurocognitive tests based on the Syndrom Kurztest (SKT) were carried out. During the ICU stay and shortly after discharge from the ICU, the delirious state was evaluated daily using the Delirium-Rating-Scale. NSE and S100b levels were assayed before CPB, 24 hours and 48 hours post-operatively and on the day before discharge.

Results: After the CPB, 1 day before discharge, six (17.6%) participants had sub-threshold cognitive deficits and seven (20.6%) had clinically significant cognitive deficits. A trend toward persistently high NSE levels at discharge indicates greater cognitive impairment at the time of discharge. After surgical intervention S100b is elevated in all patients, independent of cognitive status.

Conclusions: Persistently high levels of NSE might be a useful biomarker to identify patients with cognitive performance impairments, while no significant correlation between levels of S100b and impaired cognitive function were found.

Abbreviations
AVR=

aortic valve replacement

CABG=

coronary artery bypass graft

CPB=

cardiopulmonary bypass

DRS=

Delirium-Rating-Scale

ICU=

intensive care unit

NSE=

neuron-specific enolase

S100b=

S100 calcium-binding protein B

SD=

standard deviation

SKT=

‘Syndrom-Kurz Test’, cognitive performance test.

Abbreviations
AVR=

aortic valve replacement

CABG=

coronary artery bypass graft

CPB=

cardiopulmonary bypass

DRS=

Delirium-Rating-Scale

ICU=

intensive care unit

NSE=

neuron-specific enolase

S100b=

S100 calcium-binding protein B

SD=

standard deviation

SKT=

‘Syndrom-Kurz Test’, cognitive performance test.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.