Randomized Double-Blind Clinical Trial of Autologous Serum Versus Artificial Tears in Dry Eye Syndrome

Abstract

Purpose: To determine symptoms improvement in dry eye patients with short-term autologous serum (AS) eyedrops treatment using the standardized Ocular Surface Disease Index (OSDI) survey.

Materials and methods: A double-blind randomized crossover clinical trial was conducted, comparing short-term (2 weeks) topical treatment with AS eyedrops diluted at 20% versus conventional artificial tears treatment in adult severe dry eye syndrome (DES) patients. The main outcome measure was assessment of symptoms with OSDI survey. Secondary outcomes were corneal and conjunctival fluorescein staining score of OXFORD and tear break up time (TBUT). The protocol was registered in www.clinicaltrials.gov, ID number: NCT00779987.

Results: Twelve severe DES patients were included. Autologous serum treatment showed a statistically significant (p = 0.002) higher OSDI decrease (50%) versus conventional treatment (22%). There were no significant changes in objectives parameters (OXFORD and TBUT).

Conclusions: Severe DES patients treated with AS achieve better symptoms improvement compared to artificial tears in a short-term treatment.

KEYWORDS::

• Artificial tears
• Autologous serum
• Dry eye syndrome
• Ocular surface
• OSDI

ACKNOWLEDGMENTS

The authors want to acknowledge Dr. Luis Sotelo, for his support in manuscript preparation.

Declaration of interest: Dario H. Vasquez received a grant from CONICYT, Government of Chile, and Faculty of Medicine, University of Chile. The authors report no conflict of interest. The authors alone are responsible for the content and writingg of the paper.