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Current Eye Research Volume 38, 2013 - Issue 2
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Metabolic Profile of Keratoconic Cornea

Tomasz KryczkaDepartment of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology TrondheimNorway;Department of Experimental Pharmacology, Mossakowski Medical Research Centre, Polish Academy of Sciences WarsawPolandCorrespondence[email protected]
,
Niels EhlersDepartment of Ophthalmology, Aarhus University Hospital AarhusDenmark
,
Kim NielsenDepartment of Ophthalmology, Aarhus University Hospital AarhusDenmark
,
Edward WylegalaDepartment of Ophthalmology, District Railway Hospital KatowicePoland
,
Dariusz DobrowolskiDepartment of Ophthalmology, District Railway Hospital KatowicePoland
&
Anna MidelfartDepartment of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology TrondheimNorway;Department of Ophthalmology, University Hospital TrondheimNorway
Pages 305-309 | Received 31 May 2012, Accepted 25 Nov 2012, Published online: 17 Jan 2013
 
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Abstract

Purpose: To investigate the difference in metabolic profile of keratoconic and normal corneas using two different analysis methods.

Methods: Keratoconic corneas were obtained from patients (aged 19–27) during transplantation surgery. Control samples were obtained from human donors (aged 61–75) 1–8 h post-mortem. The metabolic profile of tissues was investigated with high-resolution magic angle spinning 1H nuclear magnetic resonance (NMR) spectroscopy and high performance liquid chromatography (HPLC).

Results: Nine amino acids and 20 metabolites were assigned with HPLC and NMR spectroscopy, respectively. No significant biochemical difference was revealed between keratoconic and control samples, which represent distant age groups.

Conclusions: It suggests that development of keratoconus might be related to the accelerated ageing of the cornea. This issue warrants further studies.

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